2000 chevy express 5.0 2500 series starts,runs and dies all in 10 seconds. changed fuel pump, filter, pressure regulator, and starter(only cause sparks were comming from the solenoid)

Good question. Many things to eliminate. You might want to have a mechanic narrow this down with a diagnosis. Otherwise, here are possible causes:

Fuel pressure regulator: If the fuel pressure regulator is faulty, it can cause the engine to start and then stall immediately. You may want to check the fuel pressure regulator to see if it's working properly.

Fuel pump relay: A faulty fuel pump relay can cause the engine to start and then stall immediately. You may want to check the fuel pump relay to see if it's working properly.

Crankshaft position sensor: If the crankshaft position sensor is faulty, it can cause the engine to start and then stall immediately. You may want to check the crankshaft position sensor to see if it's working properly.

Ignition switch: A faulty ignition switch can cause the engine to start and then stall immediately. You may want to check the ignition switch to see if it's working properly.

Battery: If the battery is weak or dead, it can cause the engine to start and then stall immediately. You may want to check the battery to see if it's working properly.

Fuel filter: A clogged fuel filter can cause the engine to start and then stall immediately. You mentioned that you already changed the fuel filter, but it's possible that there's still an issue with it.

Vacuum leak: A vacuum leak can cause the engine to start and then stall immediately. You may want to check for any vacuum leaks in your truck.

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You may be having an intermittent failure with the fuel pressure regulator - checking the fuel pressure when the truck won't start may pinpoint this problem. If the pressure looks OK, this same problem can be caused by the ignition system as well (ignition coil or control module).

You may want to do a fuel pressure test to start. The pump could be defective. The fuel pressure should hold steadily and not decline with the pump off. If the fuel pressure falls, you either have a fuel leak, stuck injector, faulty fuel pressure regulator, or a bad fuel pump check valve. If the pressure holds at the correct spec, note the pressure as the engine runs and then dies. If the guage shows correct pressure, you can then move on ruling out the fuel system.

I have 2000 Chevy blazer 4.3 l v6 vortex I had the same problem I would spray starter fluid into the air flirted canester Nd it would start as soon as I stopped spraying the fluid the engine would die first I checked to make sure my gas pump was working in the gas tank second I checked my fuses under the hood and last the fuel pressure so my gas pump was on in the tank fuses were also ok but I had no pressure on the gas line so that ment my gas pump was bad I replaced it after replacing it my blazer fires problems free now

Will it run for a short time if you squirt some fuel into the throttle body? If so, then concentrate on the fuel delivery system. Fuel pressure at the test port on the fuel rail should be at least 40 PSI. If not, look at the fuel pump, the pressure regulator, and the fuel filter.

try replacing the fuel regulator,or is the oil cap on tight?the fuel regulator works on base vacumm

Have you checked the fuel filter? Have you changed it EVER?

hi i have a 1997 chevy tahoe that starts but won't stay running i have changed fuel pump, fuel filter,relay ,spark plugs, and just changed rotor and dis. cap ready need some help to figure this out please.

I have had similar problems and had to replace the fuel pressure regulator. It's a major expense because it sets below the diaphram in the intake manifold. Ask your mechanic about it, it may be the issue. I would get about 30,000 miles between replacement, I've replace it 3 times since purchasing the 2000 chevy blazer new, first one was under warranty.