As a general rule the cage should be at least 4 times the size of the rabbit, but if your house permits - bigger is better. This is true especially if the rabbits will spend most of their time in the cage.
As a guide: larger rabbits need a cage of 30" by 36" and smaller rabbits (Less than 8 lbs): 24" by 36".
Try this great guide: http://www.therabbithouse.com/guide_size.asp
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